Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Article Title: Analysis of the intended and actual orientations of directional deep brain stimulation leads across deep brain stimulation systems

doi: 10.1109/EMBC48229.2022.9871608

Figure Lengend Snippet: (A) Boston Scientific Cartesia™ and St. Jude Medical Directed 6172 directional leads and the CT artifacts seen at the level of the marker and segmented electrodes, (B) Distributions of the actual orientations calculated with DiODe for leads intended to face anterior (C) Distributions of deviation between the actual and intended orientations for both DBS systems as calculated by each user (K.H. and M.M.), (D) the agreement of actual orientations calculated by each user, K.H. and M.M., for the Boston Scientific (red points) and St. Jude (blue points) leads.

Article Snippet: When localizing the postoperative leads with DiODe, large deviations of up to 90° have been reported between the intended and actual orientations in patients implanted with Cartesia TM directional DBS leads (Boston Scientific, USA) [ 8 ].

Techniques: Marker

Journal: Stereotactic and functional neurosurgery

Article Title: Factors Influencing Electrode Position and Bending of the Proximal Lead in Deep Brain Stimulation for Movement Disorders

doi: 10.1159/000507029

Figure Lengend Snippet: Participants’ demographics, lead target and model, and surgery details. DBS = Deep Brain Stimulation, DYS = Dystonia, ET = Essential tremor, PD = Parkinson’s disease, GPi = Globus Pallidus interna, STN = Subthalamic nucleus, VIM = Ventral intermediate nucleus, MDT = Medtronic, BSC = Boston Scientific, ABT = Abbott Laboratories.

Article Snippet: Jude Medical Infinity™ DBS lead and the eight contact Boston Scientific Vercise™ DBS lead in addition to the Medtronic 3389™ DBS lead, to investigate the effect of DBS lead model on electrode position and proximal lead bowing following DBS surgery.

Techniques:

Journal: medRxiv

Article Title: Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease

doi: 10.1101/2023.02.27.23286478

Figure Lengend Snippet: (A) Line segments show within-participant changes in cognitive performance over time after DBS surgery, and bold lines show sample means. On tests of verbal fluency and memory, higher scores reflect improvement, while a lower score on response inhibition reflects an improved (i.e., faster) performance. p-values indicate significance of slopes over time. (B) Unity plots contrast cognitive performance with double-blind comparison of ring versus directional stimulation. p-values indicate significance of the binomial test in improvement on either stimulation setting.

Article Snippet: The same neurosurgeons (BG, JNB) implanted a 1-3-3-1 directional lead (Boston Scientific Vercise DBS system, Natick MA, USA, FDA IDE# G170063) at the STN target under local anesthesia with the patient fully awake.

Techniques: Inhibition, Comparison

Journal: medRxiv

Article Title: Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease

doi: 10.1101/2023.02.27.23286478

Figure Lengend Snippet: Binomial tests of cognitive performance by stimulation mode

Article Snippet: The same neurosurgeons (BG, JNB) implanted a 1-3-3-1 directional lead (Boston Scientific Vercise DBS system, Natick MA, USA, FDA IDE# G170063) at the STN target under local anesthesia with the patient fully awake.

Techniques: Inhibition

Journal: Neurotherapeutics

Article Title: Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation

doi: 10.1007/s13311-020-00944-0

Figure Lengend Snippet: Ongoing or upcoming interventional trials in dystonia

Article Snippet: Unlocking Dystonia from Parkinson’s Disease with Directional DBS Technology , Boston Scientific Vercise PC IPG with directional DBS lead , University of Alabama at Birmingham, Birmingham, Alabama, USA , {"type":"clinical-trial","attrs":{"text":"NCT03409120","term_id":"NCT03409120"}} NCT03409120.

Techniques: Activity Assay, Injection, Isolation, Western Blot

Journal: Frontiers in Human Neuroscience

Article Title: MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson’s Disease Patient With Levodopa-Resistant Freezing of Gait

doi: 10.3389/fnhum.2021.676755

Figure Lengend Snippet: MR tractography-based targeting of the cuneiform nucleus. Posterior oblique (A) and sagittal (B) views of a three-dimensional reconstruction of the regional anatomy and tractography based on available template atlases in Lead DBS ( ; ; ). A model of the Boston Scientific Vercise Cartesia TM directional electrode is placed in the field targeting the cuneiform nucleus bilaterally for demonstration. CnF, cuneiform nucleus; CTT, central tegmental tract; GPi, globus pallidus internus; ML, medial lemniscus; PPN, pedunculopontine nucleus; RN, red nucleus; SCP, superior cerebellar peduncle tracts; SN, substantia nigra; STN, subthalamic nucleus; STT, spinothalamic tract. (C–G) Subject specific tractography-based targeting, visualized in Brainlab Elements software (Brainlab AG, Munich, Germany). (C) Frontal view from above of subject’s left medial lemniscus reconstruction (fuchsia) in relation to a preplanned estimate of the CnF target (blue) against a pons level axial slice of the brain. (D) Posterior view of the final electrode positions in relation to the estimated CnF target (red) and the subject’s reconstructed central tegmental tracts (light blue). (E) Frontal and (F,G) sagittal views of the final electrode positions in relation to the thalamus, substantia nigra (SN), subthalamic nuclei (STN), and CnF (red).

Article Snippet: Based on our intraoperative physiology, an octopolar directional DBS electrode (Vercise Cartesia TM , Boston Scientific) was implanted to center the directional electrodes at the region that best elicited leg EMG oscillations.

Techniques: Software